Valproic Acid-d15 - CAS 362049-65-8

Valproic Acid-d15 is a deuterated compound of Valproic Acid. Valproic Acid has a CAS number of 99-66-1. Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Endogenous Metabolite, Autophagy, Mitophagy, Gamma-secretase, HIV Protease, HDAC

Chromatin/Epigenetic, Metabolism, Proteases/Proteasome, Autophagy, Microbiology/Virology, DNA Damage/DNA Repair, Stem Cells, Neuroscience

362049-65-8

C8H1D15O2

159.3

C(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])(C(O)=O)[2H]

-20°C

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