VEGFR-2-IN-52 - CAS 3046428-94-5

VEGFR-2-IN-52 (compound 14d) serves as a powerful inhibitor of VEGFR-2, exhibiting an IC 50 of 191.1 nM. It effectively reduces the protein expression levels of p-VEGFR-2, MMP9, p-ERK1/2, and p-MEK1. In addition, VEGFR-2-IN-52 demonstrates cytotoxic properties by inducing apoptosis and arresting the cell cycle at the G0/G1 phase, and it enhances the levels of ROS.

Apoptosis, Reactive Oxygen Species, VEGFR

NF-κB, Apoptosis, Metabolism, Angiogenesis, Tyrosine Kinase/Adaptors, Immunology/Inflammation

3046428-94-5

C20H25ClN4O2S

420.96

O=C(N)C1=C(SC=C1C=2C=CC(Cl)=CC2)NC(=O)NCCCCN3CCCC3

-20°C

Ice Packs

Small Compound