Vemurafenib - CAS 918504-65-1

Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently. Vemurafenib exhibits antitumor activity and is used for the treatment of BRAF V600E mutation-positive melanoma.

Autophagy, Raf, MAPK, Src, ACK1

Angiogenesis, Tyrosine Kinase/Adaptors, MAPK, Autophagy

918438

0.9965

C23H18ClF2N3O3S

489.92

C(=O)(C=1C=2C(NC1)=NC=C(C2)C3=CC=C(Cl)C=C3)C4=C(F)C(NS(CCC)(=O)=O)=CC=C4F

-20°C

Ice Packs

Small Compound