Venetoclax - CAS 1257044-40-8

Venetoclax (ABT-199) is a Bcl-2 inhibitor (Ki<0.01 nM) with potent, selective, and orally active properties. Venetoclax has a 3-order-of-magnitude lower affinity for Bcl-xL and Bcl-W (Kis=48/245 nM) . Venetoclax induces autophagy and apoptosis.

Autophagy, Bcl-2 Family

Autophagy, Apoptosis

1256996

0.9997

C45H50ClN7O7S

868.44

O=C(C1=CC=C(N2CCN(CC2)CC3=C(CC(C)(CC3)C)C4=CC=C(Cl)C=C4)C=C1OC5=CC6=C(NC=C6)N=C5)NS(=O)(C7=CC=C(C([N+]([O-])=O)=C7)NCC8CCOCC8)=O

-20°C

Ice Packs

Small Compound