VH-298 - CAS 2097381-85-4

VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes.

Ligand for E3 Ligase, HIF/HIF Prolyl-Hydroxylase, HIF

Angiogenesis, PROTAC, Metabolism, Chromatin/Epigenetic

2097292

>99.99%

C27H33N5O4S

523.65

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(CC2)C#N)C(C)(C)C)cc1

-20°C

Ice Packs

PROTAC