VHL Ligand 8 - CAS 2701565-76-4

VHL Ligand 8, a VHL ligand essential for synthesizing ARD-266, acts as a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. It efficiently facilitates the degradation of AR protein in AR-positive prostate cancer cell lines LNCaP, VCaP, and 22Rv1, exhibiting DC50 values ranging from 0.2-1 nM [1].

Others, Ligand for E3 Ligase

PROTAC, Others

2701485

C23H29N3O6

443.49

C([C@H](C(C)C)C=1ON=C(C)C1)(=O)N2[C@H](C(N[C@@H](CC(O)=O)C3=CC=CC=C3)=O)C[C@@H](O)C2

-20°C

Ice Packs

PROTAC