(-) -Viriditoxin - CAS 1381782-08-6

(-) -Viriditoxin is a mycotoxin originally isolated from A. viridinutans that has antibacterial and antiproliferative activity. It is active against methicillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 μg/ml) . (-) -Viriditoxin is also active against fish pathogens, including S. iniae and S. parauberis (MICs = 0.16-0.21 μg/ml) . It inhibits polymerization and the GTPase activity of E. coli FtsZ, a tubulin-like GTPase involved in bacterial cell division (IC50s = 8.2 and 7 μg/ml, respectively) . (-) -Viriditoxin inhibits proliferation of human DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5.36, 0.63, and 7.6 μM, respectively) . It is also toxic to mice (LD50 = 2.8 mg/kg, i.p.) .

Others

Others

1381782-08-6

C34H30O14

662.6

COC(=O)CC1Cc2cc3c(c(OC)cc(O)c3c(O)c2C(=O)O1)-c1c(OC)cc(O)c2c(O)c3C(=O)OC(CC(=O)OC)Cc3cc12

-20°C

Ice Packs

Small Compound