VJ115 - CAS 929256-79-1

VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. Inhibition of ENOX1 radiosensitizes tumor vasculature, a consequence of enhanced apoptosis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cytoskeletal reorganization and angiogenesis.

Others

Others

929176

C23H24N2O

344.45

C(\C=1C=2C(N(CC3=CC=CC=C3)C1)=CC=CC2)=C/4\N5CCC(C4O)CC5

-20°C

Ice Packs

Small Compound