VNPP433-3β - CAS 1630820-51-7

VNPP433-3β acts as a molecular glue degrader, targeting the androgen receptor (AR) and its splice variants (AR-Vs) as well as MAP kinase-interacting serine/threonine protein kinase Mnk1/2. It effectively inhibits the proliferation of cancer cells LNCaP, C4-2B, and CWR22Rv1, with GI50 values of 0.2, 0.3, and 0.31 μM, respectively. Additionally, VNPP433-3β shows favorable pharmacokinetics in CD-1 mice and suppresses tumor growth in the CWR22Rv1 xenograft mouse model.

Apoptosis, Androgen Receptor, MNK, Molecular Glues

PROTAC, MAPK, Endocrinology/Hormones, Apoptosis

1630820-51-7

C29H34N4

438.61

C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(=CC3)C[C@H](CC4)N5C=CN=C5)[H])[H])(CC=C2N6C=7C(N=C6)=CC=CC7)[H]

-20°C

Ice Packs

Small Compound