VRT-043198 - CAS 244133-31-1

VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective, and blood-brain barrier permeable inhibitor of the interleukin-converting enzyme/caspase-1 subfamily caspases, displaying Ki values of 0.8 nM for ICE/caspase-1 and 0.6 nM for caspase-4, respectively.

Others, Drug Metabolite, Caspase

Others, Proteases/Proteasome, Apoptosis, Metabolism

244101

C22H29ClN4O6

480.94

CC(C)(C)[C@H](NC(=O)c1ccc(N)c(Cl)c1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C=O

-20°C

Ice Packs

Small Compound