VU0467319 - CAS 1432438-14-6

VU0467319 (Compound VU319) is a highly selective positive allosteric modulator of the M1 receptor, capable of crossing the blood-brain barrier and orally active, with an EC50 of 492 nM. It demonstrates selectivity in humans and rats (EC50 > 30 μM) compared to M2-5 receptors. This compound improves cognitive deficits associated with Alzheimer's disease (AD) through central M1 muscarinic receptor activation and does not induce cholinergic adverse effects, highlighting its potential in AD research.

AChR

Neuroscience

1432418

C22H16F2N4O

390.385

O=C1C2=CC=CN=C2CN1CC=3C(F)=CC(=CC3F)C4=CC=CC5=NN(C=C54)C

-20°C

Ice Packs

Small Compound