VU0514009 - CAS 932973-77-8

VU0514009 is a competitive antagonist of chemokine-like receptor 1 (CMKLR1) with an EC50 of 2 nM. It effectively inhibits chemerin-9-induced arrestin recruitment and receptor internalization, significantly reducing Ca2+ flux responses in HEK293 cells. This compound shows potential for research in inflammatory diseases and metabolic syndrome.

Chemerin Receptor

GPCR/G Protein

932888

C21H20ClN3O5S2

493.98

O=C1NC(=NC=C1S(=O)(=O)C2=CC=C(C(Cl)=C2)C)SCC(=O)NC3=CC(=CC=C3OC)C

-20°C

Ice Packs

Small Compound