VU6007477 - CAS 2220141-46-6

VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat brain/plasma Kp = 0.28, Kp, uu = 0.32; mouse Kp = 0.16, Kp, uu = 0.18), and no cholinergic adverse events (AEs, e.g., seizures) .

Others, P-gp

Membrane transporter/Ion channel, Neuroscience, Others

2220089

0.9967

C24H26N6O2

430.5

C(C1=C2C(=NC(C(NC3CCOCC3)=O)=C1)N(C)C=C2)C=4C=CC(=NC4)C5=CN(C)N=C5

-20°C

Ice Packs

Small Compound