VVD-849 - CAS 3055321-14-4

VVD-849 is a RAS ligand that covalently binds to cysteine at position 242 within the RAS binding domain of PI3Kp110α, enhancing RAS/PI3K interaction. It partially inhibits pAKT (S473) in tumors overexpressing HER2. VVD-849 is applicable in cancer research, including studies on breast cancer.

PI3K, Ras

PI3K/Akt/mTOR signaling, MAPK

3055303

C29H31ClFN3O6S2

636.15

S(=O)(=O)(C1=C(C=C(Cl)C=C1)C2=CC(OCC3=CC=CC=N3)=CC=C2)N4CCC(C(N[C@H](/C=C\S(C)(=O)=O)C)=O)(F)CC4

-20°C

Ice Packs

Small Compound