W-54011 - CAS 405098-33-1

W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki = 2.2 nM) . W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils (IC50s = 3.1 nM, 2.7 nM, and 1.6 nM, respectively) .

Complement System, ROS, Reactive Oxygen Species

Metabolism, Immunology/Inflammation, NF-κB

405064

0.968

C30H37ClN2O2

493.08

Cl.COc1ccc2CCCC(C(=O)N(Cc3ccc(cc3)N(C)C)c3ccc(cc3)C(C)C)c2c1

-20°C

Ice Packs

Small Compound