W4022 - CAS 2761292-51-5

W4022 (compound 16) is an efficient dual inhibitor of the lysine methyltransferases G9a/NSD2, with IC50 values of 0.241 μM for G9a and 0.017 μM for NSD2. It exhibits potent antiproliferative properties, including the ability to suppress colony formation, induce apoptosis, and inhibit metastasis of cancer cells. W4022 effectively curtails the catalytic activities of G9a and NSD2 within cells and demonstrates significant antitumor efficacy in PANC-1 xenograft models.

Histone Methyltransferase

Chromatin/Epigenetic

2761292-51-5

C25H36N6O2

452.59

N#CC=1N=C2C=C(OCCCN3CCCC3)C(OC)=CC2=C(N1)NC4CCN(CC4)C(C)C

-20°C

Ice Packs

Small Compound