WAY-255348 - CAS 872141-23-6

WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel molecular mechanism that is distinct from previously studied PR modulators and may be a useful tool to further understanding of PR signaling pathways.

Others, Progesterone Receptor

Others

872112

C16H14FN3O

283.3

CC1(C)C=2C(=C(F)C=C(C2)C=3N(C)C(C#N)=CC3)NC1=O

-20°C

Ice Packs

Small Compound