WB436B - CAS 2248552-84-1

WB436B, a highly selective STAT3 inhibitor, effectively targets and inhibits STAT3-Tyr705 phosphorylation along with the expression of STAT3 target genes. It exhibits cytotoxic effects on pancreatic cancer cells by inducing apoptosis. Furthermore, WB436B suppresses tumor growth and metastasis in pancreatic cancer mouse models, thereby prolonging the survival of tumor-bearing mice.

Apoptosis, STAT

JAK/STAT signaling, Apoptosis, Stem Cells

2248467

C21H20N6O3S

436.49

N#CC1=C(SC2=C1CCN(C(=O)NC=3C=CC=CC3OC)C2)NC(=O)C=4C=NN(C4)C

-20°C

Ice Packs

Small Compound