WDR5-0102 - CAS 824960-50-1

WDR5-0102 is a compound that inhibits the WDR5-MLL1 interface (K dis = 7 μM, K d = 4 μM), selectively reducing MLL1 HMT activity without affecting the human H3K4 methyltransferase SETD7 or other HMTs, including G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5.

JAK, Histone Methyltransferase

Chromatin/Epigenetic, JAK/STAT signaling, Stem Cells, Angiogenesis, Tyrosine Kinase/Adaptors

824909

0.9803

C18H19ClN4O3

374.82

N(C(=O)C1=C(Cl)C=CC=C1)C2=C(C=CC(N(=O)=O)=C2)N3CCN(C)CC3

-20°C

Ice Packs

Small Compound