WEE1-IN-12 - CAS 3069940-37-7

WEE1-IN-12 (Compound 87) is a Wee1 kinase inhibitor with an IC50 of 2.0 nM. It inhibits the proliferation of HT29 cells (IC50: 1.07 μM) and shows enhanced efficacy when combined with Gemcitabine (IC50: 0.34 μM) . WEE1-IN-12 is applicable in the study of tumors such as colon cancer.

Wee1

Cell Cycle/Checkpoint

3069896

C38H38Cl2N10O6

801.68

O=C(NC=1C(Cl)=CC=CC1Cl)C2=CN=C(N=C2OC3CC3)NC=4C=NN(C4)C5CCN(CCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8)CC5

-20°C

Ice Packs

Small Compound