Withanolide B - CAS 56973-41-2

Withanolide B, a natural product isolated from Withania somnifera Dunal, promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) via the ERK1/2 and Wnt/β-catenin signalling pathways, thereby enhancing bone healing. Withanolide B exhibits affinity for the catalytic domain of PARP-1.

Wnt/beta-catenin, PARP, ERK

Stem Cells, MAPK, Cytoskeletal Signaling, Chromatin/Epigenetic, DNA Damage/DNA Repair

56930

C28H38O5

454.6

[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@@H]4O[C@@H]4[C@@]4(O)CC=CC(=O)[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)[C@@]1([H])CC(C)=C(C)C(=O)O1

-20°C

Ice Packs

Natural Product