WK88-1 - CAS 958888-32-9

WK88-1, an inhibitor of Hsp90, effectively induces the degradation of various oncogenic signaling molecules, including EGFR, ErbB2, and ErbB3, in the gefitinib-resistant H1975 cell line. This leads to subsequent growth arrest and apoptosis.

Apoptosis, HSP

Apoptosis, Metabolism, Cytoskeletal Signaling

958847

C28H42N2O6

502.64

CO[C@H]1CC\C=C(C)/C(=O)NC2=CC(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)\C=C(C)\[C@H]1OC(N)=O)=CC=C2

-20°C

Ice Packs

Small Compound