WP-1034 - CAS 857064-42-7

WP-1034 is a novel Jak-Stat inhibitor, which is active against AML blasts. WP-1034 effectively inhibited proliferation of OCIM2 cells and fresh AML samples. WP-1034 caused cell cycle arrest of OCIM2 cells in sub-Go phase. WP-1034 induced apoptosis of OCIM2 cells and that induction of apoptosis involved cleavage of caspase 3 and the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) .

Others

Others

857015

C18H15N3O3

321.33

C(=C(/C(N[C@H](C)C1=CC=CC=C1)=O)\C#N)\C2=CC=C(N(=O)=O)C=C2

-20°C

Ice Packs

Small Compound