WRN-IN-19 - CAS 3058652-58-4

WRN-IN-19 (Compound (S) -27) is a covalent WRN helicase inhibitor, with a pIC50 of 5.4 at 0 hours and 7.5 at 4 hours in a DNA-unwinding endpoint assay. It demonstrates synthetic lethality against MSI-H (high microsatellite instability) cancer cells.

DNA/RNA Synthesis

DNA Damage/DNA Repair, Cell Cycle/Checkpoint

3058590

C23H26F3N3O3

449.47

C(=O)(N1CC2(C1)CCC2)[C@H]3N(C(C=C)=O)CCN(C(CC4=CC=C(C(F)(F)F)C=C4)=O)C3

-20°C

Ice Packs

Small Compound