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WRN inhibitor 11 - CAS 3058317-61-3
WRN inhibitor 11 - CAS 3058317-61-3
SKU:MF-0142860-01
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Product Details
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Bioactivity
WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.
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Target
DNA/RNA Synthesis
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Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
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CAS Number
3058253
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Molecular Formula
C34H35ClF3N9O5
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Molecular Weight
742.15
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SMILES
O=C(C1=NC=NC(=C1O)C)N2CC3N(C=4C(=O)N5N=C(N=C5N(C4CC)CC(=O)NC6=CC(Cl)=C(C=C6C)C(F)(F)F)C7=CCOCC7)C(C2)CC3
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Storage Temperature
-20°C
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Shipping Conditions
Ice Packs
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Category
Small Compound