WRR-483 - CAS 1076088-50-0

WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. WRR-483 binds covalently to the active site cysteine of the protease in a similar manner as other vinyl sulfone-based inhibitors. WRR-483 has potential to be developed as a treatment for Chagas' disease.

Others, Parasite

Others, Microbiology/Virology

1076038

C29H41N7O4S

583.75

[C@@H](NC(=O)N1CCN(C)CC1)(C(N[C@H](C=CS(=O)(=O)C2=CC=CC=C2)CCC3=CC=CC=C3)=O)CCCNC(=N)N

-20°C

Ice Packs

Small Compound