WS-11 - CAS 2759280-09-4

WS-11 is a non-covalent reversible inhibitor of BTK, with IC50 values of 3.9 nM for the wild-type and 2.2 nM for the C481S mutant BTK. In addition to strong hydrogen bonding, WS-11 also forms robust π-π interactions with PHE540, and p-π interactions with LYS430 within the active pocket.

BTK

Tyrosine Kinase/Adaptors, Angiogenesis

2759280-09-4

C26H22FN9O2

511.51

O=C1N=C(C=C1)N2CCCC(N3N=C(C=4C=CC(=CC4F)C(=O)NC5=NC=CC=C5)C=6C(=NC=NC63)N)C2

-20°C

Ice Packs

Small Compound