WS-691 - CAS 2035417-32-2

WS-691 is a highly Potent and Orally Active ABCB1 Modulator. WS-691 significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC50 = 22.02 nM) . WS-691 significantly increased the intracellular concentration of PTX and [3H]-PTX while decreasing the efflux of [3H]- PTX in SW620/Ad300 cells by inhibiting the efflux function of ABCB1. WS-691 could stabilize ABCB1 by directly binding to ABCB1 WS-691 increased the sensitivity of SW620/Ad300 cells to PTX in vivo without observed toxicity.

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Others

2035383

C20H16FN7S

405.45

N(C=1N2C(=NC(SCC=3NC=4C(N3)=CC=CC4)=N2)N=C(C)C1)C5=CC=C(F)C=C5

-20°C

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Small Compound