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Molfinity

WYE-687 - CAS 1062161-90-3

WYE-687 - CAS 1062161-90-3

MF-0014221-01

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Product Details

  • Bioactivity

    WYE-687 is an ATP-competitive and selective inhibitor of mTOR with an IC50 of 7 nM; it blocks mTORC1/pS6K (T389) and mTORC2/P-AKT (S473) without affecting P-AKT (T308) . Its selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold) .

  • Target

    Src, PI3K, p38 MAPK, mTOR

  • Related Pathways

    MAPK, Angiogenesis, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors

  • CAS Number

    1062068

  • Purity

    0.9993

  • Molecular Formula

    C28H32N8O3

  • Molecular Weight

    528.61

  • SMILES

    COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound