WYE-687 dihydrochloride - CAS 1702364-87-1

WYE-687 dihydrochloride is an ATP-competitive inhibitor of mTOR, demonstrating potent activity with an IC50 value of 7 nM. It effectively suppresses the activation of both mTORC1 and mTORC2. Additionally, WYE-687 exhibits inhibitory effects on PI3Kα and PI3Kγ, with IC50 values of 81 nM and 3.11 μM, respectively.

Others, PI3K, mTOR

PI3K/Akt/mTOR signaling, Others

1702276

C28H34Cl2N8O3

601.53

Cl.Cl.O=C(OC)NC=1C=CC(=CC1)C=2N=C3C(C=NN3C4CCN(CC=5C=NC=CC5)CC4)=C(N2)N6CCOCC6

-20°C

Ice Packs

Small Compound