WZH-15-125 - CAS 2845188-22-7

WZH-15-125 is a potent ALK inhibitor capable of overcoming resistance, particularly with complex ALK mutations. It exhibits an IC50 of 101.7 nM against the highly recalcitrant Lorlatinib-resistant G1202R/L1196M mutation. Additionally, WZH-15-125 can serve as a PROTAC target protein ligand for synthesizing PROTACWZH-17-002. This compound is applicable in non-small cell lung cancer research.

Ligands for Target Protein for PROTAC, ALK

Angiogenesis, PROTAC, Tyrosine Kinase/Adaptors

2845159

C33H45BrN8O5S

745.73

O=S(=O)(N(C1=C2OCCOC2=CC=C1NC3=NC(=NC=C3Br)NC=4C=C(C(=CC4OC)N5CCC(N6CCN(C)CC6)CC5)CC)C)C

-20°C

Ice Packs

PROTAC