XIE62-1004 - CAS 2421146-32-7

XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62. This interaction promotes p62 self-aggregation and its subsequent interaction with LC3 on autophagosome membranes, thereby facilitating the delivery of cargo proteins to the autophagosome for degradation. XIE62-1004 is effective both in vitro and in vivo, displaying specificity for the wild type of p62 and exhibiting its actions in a concentration- and time-dependent manner. Additionally, it induces the degradation of mutant huntingtin in vitro and can be employed in AUTAC protein degradation systems to trigger autophagy via p62 self-aggregation and LC3 interaction.

Others, Autophagy, ATG, p62

Others, Autophagy

2421146-32-7

C23H25NO3.HCl

399.91

Cl.OCCNCC1=CC=C(OCC=2C=CC=CC2)C(OCC=3C=CC=CC3)=C1

-20°C

Ice Packs

Small Compound