XL-188 - CAS 2305045-76-3

XL-188 is a highly potent and selective inhibitor of USP7. XL188 inhibited USP7 catalytic domain and full-length enzyme with IC50 values of 193 and 90 nM, respectively. XL188 Promotes USP7-Dependent Loss of HDM2 and Increase of p53 and p21. XL188 represents one of only a small set of mammalian DUB inhibitors with low nanomolar potency and a high degree of selectivity relative to other DUBs

Others, DUB

Cell Cycle/Checkpoint, Ubiquitination, Others, DNA Damage/DNA Repair

2304966

C32H42N6O4

574.71

O=C1C=2C(=CC(NC(CCN3CCN(C)CC3)=O)=CC2)N=CN1CC4(O)CCN(C(C[C@@H](C)C5=CC=CC=C5)=O)CC4

-20°C

Ice Packs

Small Compound