XL44 - CAS 2637949-91-6

XL44, as an hRpn13 binder, triggers hRpn13-dependent apoptosis and limits cell viability via a PCLAF-dependent mechanism. It causes ubiquitin-dependent degradation of hRpn13 Pru and ubiquitin-independent degradation of specific KEN box-containing proteins [1].

Apoptosis

Apoptosis

2637949-91-6

C23H17FN2O3

388.39

C(=C1C=2C(NC1=O)=CC=C(F)C2)C3=CC(NC(=O)C4=CC=C(OC)C=C4)=CC=C3

-20°C

Ice Packs

Small Compound