XMD15-44 - CAS 1240489-67-1

XMD15-44, a RET kinase inhibitor, demonstrates potent growth-inhibitory effects on RAT1 cells transformed by RET/C634R and RET/M918T, with IC50 values of 11.5 nM and 8.3 nM, respectively. It effectively inhibits RET kinase activity and signaling in human thyroid cancer cell lines harboring oncogenic RET alleles, thereby reducing cell proliferation.

C-RET

Tyrosine Kinase/Adaptors, Apoptosis

1240421

C29H29F3N4O

506.56

O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C3=CC=C(C(C#CC=4C=NC=CC4)=C3)C

-20°C

Ice Packs

Small Compound