XRD-0394 - CAS 2595308-10-2

XRD-0394 is a highly effective and selective dual inhibitor of ATM and DNA-PKcs, exhibiting oral bioactivity. It notably increases tumor cell destruction both in vitro and in vivo when combined with therapeutic ionizing radiation. Furthermore, XRD-0394 enhances the efficacy of PARP and topoisomerase I inhibitors in vitro [1].

ATM/ATR, DNA-PK

DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling

2595308-10-2

C26H30FN5O4S

527.61

O=C1C2(C=3C=4C(N=CC3N1C)=CC(F)=C(C4)C=5C=C(NS(C)(=O)=O)C(OCCNC(C)C)=NC5)CCC2

-20°C

Ice Packs

Small Compound