XSJ05 - CAS 1461652-87-8

XSJ05, a derivative of camptothecin (CPT), exhibits anti-cancer activity by inhibiting topoisomerase I (Topo I) . This compound induces DNA double-strand breaks, leading to DNA damage. Furthermore, XSJ05 stifles the growth of colorectal cancer (CRC), halts the cell cycle in the G2/M phase, and induces apoptosis.

Topoisomerase, Apoptosis

DNA Damage/DNA Repair, Apoptosis

1461557

C29H25N5O4S

539.6

O=C1N2C(C=3C(C2)=C(C=NNC(NC4=CC=C(C)C=C4)=S)C=5C(N3)=CC=CC5)=CC6=C1COC(=O)[C@@]6(CC)O

-20°C

Ice Packs

Small Compound