XT2 - CAS 2582816-37-1

XT2 is a highly potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK), exhibiting an IC50 of 9.1 nM. It effectively suppresses the upregulation of ALT, a vital biomarker for acute liver injury, induced by CCl4. Additionally, XT2 significantly decreases immune cell infiltration into the damaged liver tissue. As a result, XT2 holds immense potential in liver inflammatory disease research [1].

Others, NF-κB

Others, NF-κB

2582778

C19H14FN5OS

379.41

C[C@@](O)(C#Cc1ccc(F)c(c1)-c1c[nH]c2cnc(N)nc12)c1nccs1

-20°C

Ice Packs

Small Compound