YB-3–17 - CAS 2940242-88-4

YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC50 of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)

MTOR, PROTACs

PROTAC, PI3K/Akt/mTOR signaling

2940150

C38H39N11O6

745.786

O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)NCC4CCC(C(=O)N5CCC(N6N=C(C=7C=CC=8OC(=NC8C7)N)C=9C(=NC=NC96)N)CC5)CC4)CC1

-20°C

Ice Packs

PROTAC