YF135 - CAS 2913177-53-2

YF135, a reversible-covalent KRAS G12C PROTAC, effectively induces the degradation of KRAS G12C and reduces phospho-ERK levels via the E3 ligase VHL-mediated proteasome pathway. Designed by integrating the KRAS G12C inhibitor 48 (compound 6d) as the ligand, YF135 utilizes the MRTX849 linkage VHL ligand scaffold.

Ras, PROTACs, Others, Kras, PERK

MAPK, PROTAC, Others, Apoptosis

2913122

C63H75ClN12O7S

1179.86

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCN2CCC[C@H]2COc2nc3CN(CCc3c(n2)N2CCN([C@@H](CC#N)C2)C(=O)C(=C\C2CC2)\C#N)c2cccc3cccc(Cl)c23)C(C)(C)C)cc1

-20°C

Ice Packs

PROTAC