YLL545 - CAS 1423126-69-5

YLL545 is an inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) . It inhibits VEGF-induced phosphorylation of VEGFR2 and the activation of downstream signaling mediators (such as phosphorylated STAT3 and phosphorylated ERK1/2) in human umbilical vein endothelial cells (HUVEC) . Additionally, YLL545 suppresses HUVEC proliferation, migration, invasion, and angiogenesis. It also induces apoptosis and inhibits tumor growth in a mouse model of breast cancer.

STAT, ERK, Apoptosis, VEGFR

Tyrosine Kinase/Adaptors, JAK/STAT signaling, MAPK, Stem Cells, Apoptosis, Angiogenesis

1423126-69-5

C19H13F3N6O2

414.34

O=C(NC1=CC=C(OC2=NC=NC=3NN=CC23)C=C1)NC4=CC=CC(=C4)C(F)(F)F

-20°C

Ice Packs

Small Compound