YM-344031 - CAS 671204-98-1

YM-344031 is an orally administered antagonist targeting CCR3. It effectively inhibits the binding of Eotaxin-1 and RANTES to CCR3, with IC50 values of 3.0 and 16.3 nM, respectively. YM-344031 also suppresses ligand-induced increases in intracellular Ca [2+] levels and chemotaxis, alters eosinophil morphology induced by eotaxin-1 in macaque blood, and prevents allergic skin reactions in a mouse allergy model.

CCR

Immunology/Inflammation, Microbiology/Virology, GPCR/G Protein

671204-98-1

C29H31FN4O3

502.58

C(C1=CC2=C(C=C1)C=C(F)C=C2)N3C[C@H](NC(C=C4CCN(C(=O)C5=C(C)C=CC=N5=O)CC4)=O)CC3

-20°C

Ice Packs

Small Compound