YM49598 - CAS 738575-62-7

YM49598 is a tachykinin receptor antagonist. YM49598 exhibited high binding affinities at NK (1) (pK (i) = 9.09 +/- 0.02) and NK (2) (pK (i) = 9.94 +/- 0.03) receptors, respectively. YM49598 was almost inactive but produced a potent inhibition (IC (50) = 11 +/- 7 microg x kg (-1) ) of the contraction of the rat urinary bladder induced by challenge with the NK (1) -selective receptor agonist [Sar9, Met (O (2) ) 11]substance P sulphone (0.3 microg x kg (-1) ) .

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Others

738506

C36H45Cl2N2O2

608.66

C(C[N+]1(C)CCC(CC1)C2=CC=CC=C2)C3(CN(C(CC4=CC(OC(C)C)=CC=C4)=O)CCC3)C5=CC(Cl)=C(Cl)C=C5

-20°C

Ice Packs

Small Compound