Yoda2 - CAS 3081450-95-2

Yoda2 (KC289), the potassium salt of Yoda1, is an agonist of PIEZO1 with an EC50 of 150 nM. It induces Ca2+ elevation in HeLa cells and can cause concentration-dependent and NO-dependent relaxation in mouse portal vein (EC50= 1.2 μM) . Additionally, Yoda2 is capable of stimulating NOS3 and promoting NO production.

Piezo Channel, NO Synthase

Membrane transporter/Ion channel, Immunology/Inflammation

3081353

C16H9Cl2KN2O2S2

435.39

O=C(C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1)[O-].[K+]

-20°C

Ice Packs

Small Compound