YS-363 - CAS 2470908-90-6

YS-363 is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor (EGFR), with half-maximal inhibitory concentrations (IC50) of 0.96 nM for the wild-type EGFR and 0.67 nM for the L858R mutant variant. It induces G0/G1 cell cycle arrest and apoptosis in targeted cells [1].

EGFR, Apoptosis

JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis

2470812

C30H30N4O3

494.58

N=1C=NC(=C2C=C(OCCCN3CCOCC3)C(OC)=CC12)C=4C=5C=CC=CC5NC4C=6C=CC=CC6

-20°C

Ice Packs

Small Compound