YT 6-2 - CAS 2409959-90-4

YT 6-2 is an autophagy-targeting ligand (ATL) aimed at p62/SQSTM1, used in the synthesis of AUTOTAC degrader ATC-324. ATC-324 induces the formation of AR/p62 complexes, leading to the autophagic-lysosomal degradation of AR. It reduces nuclear AR levels, downregulates the expression of AR and AR-v7 target genes, and also degrades common AR mutants in PCa.

AUTACs

PROTAC

2409865

C25H27F2NO5

459.48

O(CC1=CC=C(F)C=C1)C2=C(OCC3=CC=C(F)C=C3)C=CC(OC[C@@H](CNCCO)O)=C2

-20°C

Ice Packs

PROTAC