YW3-56 (hydrochloride) (technical grade) - CAS 2309756-20-3

YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively) .1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2

Autophagy, MDM-2/p53, mTOR, PAD, Others, PERK

Others, PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, Apoptosis, Autophagy

2309733

C27H33Cl2N5O2

530.49

Cl.CN(C)c1ccc2cc(ccc2c1)C(=O)N[C@@H](CCCNC(=N)CCl)C(=O)NCc1ccccc1

-20°C

Ice Packs

Small Compound