YX-02-030 - CAS 3049076-98-1

YX-02-030M is a PROTACMDM2 degrader. It inhibits the binding of MDM2 to p53 and VHL to HIF1α, with IC50 values of 63 nM and 1.35 μM, respectively. YX-02-030M binds to MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, effectively killing p53 mutant or deficient triple-negative breast cancer (TNBC) cells.

MDM-2/p53, PROTACs

Apoptosis, PROTAC

3048977

C66H85Cl2N9O10S

1267.41

C[C@@]1(N(C(=O)N2CCN(CC(NCCOCCOCCOCC(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C5=C(C)N=CS5)=O)C[C@@H](O)C3)[C@@](C)(C)C)=O)=O)CC2)C(=N[C@@]1(C)C6=CC=C(Cl)C=C6)C7=C(OCC)C=C(C(C)(C)C)C=C7)C8=CC=C(Cl)C=C8

-20°C

Ice Packs

PROTAC