YXG-158 - CAS 2952994-34-0

YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1.28 μM and CYP17A1 inhibition with an IC50 of 100 nM. It is under investigation for potential use in research on enzalutamide-resistant prostate cancer [1].

Androgen Receptor

Endocrinology/Hormones

2952960

C30H36FN3O

473.62

C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](NC(=O)C5=CC=C(F)C=C5)CC4)(CC1)[H])[H])(CC=C2N6C=C(C)N=C6)[H]

-20°C

Ice Packs

Small Compound