YZ129 - CAS 1643120-60-8

YZ129, a glioblastoma inhibitor, targets the HSP90-calcineurin-NFAT pathway by directly binding to heat shock protein 90 (HSP90) and exhibits an IC 50 of 820 nM on NFAT nuclear translocation. It induces cell-cycle arrest at the G2/M phase in GBM cells, leading to apoptosis and inhibiting tumor cell proliferation and migration [1].

Others, Apoptosis, HSP

Metabolism, Apoptosis, Others, Cytoskeletal Signaling

1643052

C19H12N2O2

300.31

O=C1C=C(Nc2ccc3cnccc3c2)c2ccccc2C1=O

-20°C

Ice Packs

Small Compound